Lewandowski M H, Zmuda L
Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
Acta Neurobiol Exp (Wars). 1995;55(2):141-5. doi: 10.55782/ane-1995-1069.
We studied the effect of intravenous injection of the cholinesterase inhibitor galanthamine (GAL) in doses from 0.025 to 5.0 mg/kg on electrically evoked field potentials in rat visual cortex. In all the experiments the amplitude of late components of evoked potentials was significantly reduced, while early components remained unaffected. These findings indicate that cortical cells are inhibited by acetylcholine (ACh). Furthermore, combined application of a muscarinic receptor blocker (atropine) and GAL reliably suppressed the effects of galanthamine. These observations suggest that ACh-induced inhibition may be mediated by activation of GABAergic interneurones that possess muscarinic receptors.
我们研究了静脉注射剂量为0.025至5.0毫克/千克的胆碱酯酶抑制剂加兰他敏（GAL）对大鼠视觉皮层电诱发场电位的影响。在所有实验中，诱发电位晚期成分的幅度显著降低，而早期成分未受影响。这些发现表明皮层细胞受到乙酰胆碱（ACh）的抑制。此外，毒蕈碱受体阻滞剂（阿托品）与GAL联合应用可可靠地抑制加兰他敏的作用。这些观察结果表明，ACh诱导的抑制可能是由具有毒蕈碱受体的GABA能中间神经元的激活介导的。
