Chen I S, Lin Y C, Tsai I L, Teng C M, Ko F N, Ishikawa T, Ishii H
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
Phytochemistry. 1995 Jul;39(5):1091-7. doi: 10.1016/0031-9422(95)00054-b.
Six new coumarins, schinicoumarin, acetoxyaurapten, epoxycollinin, schininallylol, schinilenol and schinindiol, along with seven known coumarins, aurapten, collinin, epoxyaurapten, hydrangetin, umbelliferone, acetoxycollinin and aesculetin dimethyl ether, three known alkaloids, norchelerythrine, dictamnine and skimmianine, and two triterpenoids, beta-amyrin and friedelin, were isolated and characterized from the chloroform-soluble part of the bark of Zanthoxylum schinifolium. The structures of these compounds were elucidated by spectral analyses. Separation accompanied by bioassay-guided fractionation resulted in the isolation of seven compounds with strong inhibitory activity on platelet aggregation in vitro. These are schinicoumarin, acetoxyaurapten, schininallylol, aurapten, collinin, (-)-acetoxycollinin and dictamnine.
从青花椒树皮的氯仿可溶部分分离并鉴定出6种新香豆素，即花椒新香豆素、乙酰氧基奥普托烯、环氧茵芋苷、花椒新里洛醇、花椒新烯醇和花椒新二醇，以及7种已知香豆素，即奥普托烯、茵芋苷、环氧奥普托烯、北美圣草素、伞形花内酯、乙酰氧基茵芋苷和七叶苷二甲醚，3种已知生物碱，即去甲白屈菜红碱、白鲜碱和茵芋碱，还有2种三萜类化合物，即β-香树脂醇和木栓酮。通过光谱分析阐明了这些化合物的结构。通过生物活性导向的分离，分离出了7种对体外血小板聚集具有强抑制活性的化合物。它们是花椒新香豆素、乙酰氧基奥普托烯、花椒新里洛醇、奥普托烯、茵芋苷、(-)-乙酰氧基茵芋苷和白鲜碱。
