Tsai I L, Wun M F, Teng C M, Ishikawa T, Chen I S
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
Phytochemistry. 1998 Aug;48(8):1377-82. doi: 10.1016/s0031-9422(97)00678-x.
Examination on the wood of Formosan Toddalia asiatica led to the isolation of 30 compounds, including coumarins, alkaloids, a benzoquinone and an amine. Among the isolates, (+/-)-toddanin and (-)-isocoreximine are new compounds, while cyclohexylamine was isolated for the first time from nature. The structures of the compounds were elucidated from spectroscopic data and chemical evidence. Bioassay-guided fractionation led to the isolation of seven compounds showing strong anti-platelet aggregation activity in vitro.
对台湾飞龙掌血木材进行的研究分离出了30种化合物，包括香豆素、生物碱、一种苯醌和一种胺。在这些分离物中，(±)-飞龙掌血宁和(-)-异紫堇啡碱是新化合物，而环己胺是首次从自然界中分离得到。通过光谱数据和化学证据阐明了这些化合物的结构。生物活性导向的分离得到了7种在体外显示出强抗血小板聚集活性的化合物。
