Wang T A, Li J J
Department of Biochemistry, University of California, San Francisco 94143-0448, USA.
Curr Opin Cell Biol. 1995 Jun;7(3):414-20. doi: 10.1016/0955-0674(95)80098-0.
Recent discoveries suggest that the initiation of eukaryotic DNA replication involves at least two steps--one occurring near the completion of mitosis and the other at the onset of S phase--that bring about the ordered assembly of initiator proteins at the origin. The identification and characterization of components involved in promoting or antagonizing each of these steps has provided a preliminary understanding of how replication initiation is regulated so precisely during the cell cycle.
最近的发现表明，真核生物DNA复制的起始至少涉及两个步骤——一个发生在有丝分裂接近完成时，另一个发生在S期开始时——这导致起始蛋白在起始点有序组装。对促进或拮抗这些步骤中每一个步骤的成分的鉴定和表征，为初步了解细胞周期中复制起始是如何被精确调控提供了帮助。
