Brewer B J
Department of Genetics, University of Washington, Seattle 98195.
Curr Opin Genet Dev. 1994 Apr;4(2):196-202. doi: 10.1016/s0959-437x(05)80045-0.
Replication in eukaryotes initiates at many origins per chromosome. The locations of most of these origins appear to be restricted to intergenic spacers. In this review, I propose that the sequence dependence of initiation seen in lower eukaryotes may be a by-product of the small size of intergenic sequences and may not reflect a general requirement of the mechanisms that control the initiation of replication.
真核生物中的复制在每条染色体的多个起始点启动。这些起始点中的大多数位置似乎局限于基因间隔区。在这篇综述中，我提出在低等真核生物中观察到的起始的序列依赖性可能是基因间序列小尺寸的副产物，可能并不反映控制复制起始机制的一般要求。
