D'Incan M, Antoniotti O, Gasmi M, Fonck Y, Chassagne J, Desgranges C, Souteyrand P
Laboratory of Research on Hepatitis, AIDS and Human Retroviruses, INSERM U 271, Lyon, France.
Br J Dermatol. 1995 Jun;132(6):983-8. doi: 10.1111/j.1365-2133.1995.tb16960.x.
Human T-lymphotropic virus type I (HTLV-I) is endemic in the Caribbean region, south-western Japan and Africa, and is associated with tropical spastic paraparesis and adult T-cell leukaemia/lymphoma (ATLL). Cutaneous forms of ATLL are sometimes indistinguishable from other cutaneous T-cell lymphomas (CTCL). We report a woman living in a non-endemic area for HTLV-I, with no risk factors for viral infection, who developed mycosis fungoides-like ATLL. The findings underline the usefulness of molecular biological techniques in distinguishing between mycosis fungoides and ATLL. We emphasize the need to establish the HTLV-I status of patients with CTCL, even in HTLV-I non-endemic areas, not only to establish a preventive policy in these countries, but also to further our knowledge of the lymphoproliferation spectrum associated with human retroviruses.
人类嗜T淋巴细胞病毒I型（HTLV-I）在加勒比地区、日本西南部和非洲呈地方性流行，并与热带痉挛性截瘫及成人T细胞白血病/淋巴瘤（ATLL）相关。ATLL的皮肤型有时与其他皮肤T细胞淋巴瘤（CTCL）难以区分。我们报告了一名居住在HTLV-I非流行地区、无病毒感染风险因素的女性，她患上了蕈样肉芽肿样ATLL。这些发现强调了分子生物学技术在区分蕈样肉芽肿和ATLL方面的实用性。我们强调，即使在HTLV-I非流行地区，也有必要确定CTCL患者的HTLV-I状态，这不仅是为了在这些国家制定预防政策，也是为了增进我们对与人类逆转录病毒相关的淋巴增殖谱的了解。
