Suppr超能文献

骨质疏松症的流行病学。对药物治疗的启示。

Epidemiology of osteoporosis. Implications for drug therapy.

作者信息

Rungby J, Hermann A, Mosekilde L

机构信息

Department of Endocrinology and Metabolism, University Hospital, Aarhus, Denmark.

出版信息

Drugs Aging. 1995 Jun;6(6):470-8. doi: 10.2165/00002512-199506060-00007.

Abstract

Osteoporosis represents a major health problem. Fractures secondary to decreased bone mass and disrupted bone structure vastly increase morbidity in postmenopausal women, and morbidity as well as mortality in elderly people of either sex. Prophylaxis is possible, and indeed appears to be vital to ensure a high peak bone mass. Peak bone mass is reached during the second or third decade of life, i.e. 20 to 50 years before the appearance of osteoporotic fractures. Exercise and a sufficient calcium intake are possible measures in the early years. During menopause, estrogen replacement therapy will delay the accelerated bone loss and, most likely, also osteoporotic fractures. In established osteoporosis, a number of well documented therapies are now available. Depending on the age of the patient, bisphosphonates, calcitriol or other vitamin D preparations, calcium and calcitonin may be employed. This article reviews the epidemiology of osteoporotic fractures with special reference to the therapeutic implications.

摘要

骨质疏松症是一个重大的健康问题。骨量减少和骨结构破坏继发的骨折极大地增加了绝经后女性的发病率,以及老年男女的发病率和死亡率。预防是可行的,而且对于确保达到较高的骨峰值似乎至关重要。骨峰值在生命的第二个或第三个十年达到,即在骨质疏松性骨折出现前20至50年。早年可行的措施包括运动和充足的钙摄入。在绝经期间,雌激素替代疗法将延缓加速的骨质流失,而且很可能还能延缓骨质疏松性骨折的发生。在已确诊的骨质疏松症中,现在有许多有充分文献记载的治疗方法。根据患者年龄,可使用双膦酸盐、骨化三醇或其他维生素D制剂、钙和降钙素。本文特别参考治疗意义综述了骨质疏松性骨折的流行病学。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验