Kazimirovskaia V B, Semenova N V, Moskvitina L T, Nepsha V D, Novikova N V, Voronkov M G
Eksp Klin Farmakol. 1995 May-Jun;58(3):37-40.
Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.
研究了虾夷地取代的芳氧基链烷羧酸的三（2-羟乙基）铵盐在生物胺影响下对体外血小板聚集以及脂质过氧化的作用。在体内评估了血液凝固情况。所测试的药物被证明不是一类有前景的血小板聚集抑制剂。它们具有抗氧化作用，通过降低诱导的高聚集状态下丙二醛的水平和脂质过氧化速率来实现。给动物用药时，这些药物会降低凝血酶原因子的活性。
