Aksenova V M, Gogoleva O I
Gig Tr Prof Zabol. 1992(2):25-7.
A three-fold increased level of malonic dialdehyde was found in platelets of patients suffering from the first stage of vibration disease, exposed to local vibration. The changes of the fermentative and nonfermentative lipid peroxidation (LPO) were: increased accumulation of malonic dialdehyde (by 2.5 times in ascorbate-dependent LPO and by 2.6 times in NADRH-dependent LPO). Patients with peripheral vasomotor dystonia of the upper limbs combined with vasomotor spasms of the fingers showed NADPH-dependent and ascorbate-dependent LPO respectively 41% and 29% more activated than in patients having no vasomotor spasms. In patient with vibration disease antioxidant activity was reduced by 39% on average, platelet aggregation, both spontaneous and induced by epinephrine, aggristine or adenosinediphosphoric acid, was increased. Platelet hyperaggregation in vibration disease may be caused by stimulated LPO in platelets, amassed end toxic product of LPO, decreased antioxidant activity.
在患有振动病第一阶段且暴露于局部振动的患者血小板中，发现丙二醛水平增加了两倍。发酵性和非发酵性脂质过氧化（LPO）的变化如下：丙二醛积累增加（在依赖抗坏血酸的LPO中增加2.5倍，在依赖NADRH的LPO中增加2.6倍）。上肢外周血管舒缩障碍合并手指血管舒缩痉挛的患者，其依赖NADPH的LPO和依赖抗坏血酸的LPO分别比无血管舒缩痉挛的患者激活程度高41%和29%。在振动病患者中，抗氧化活性平均降低39%，血小板聚集（包括自发聚集以及由肾上腺素、阿胍斯汀或二磷酸腺苷诱导的聚集）增加。振动病中的血小板过度聚集可能是由血小板中受刺激的LPO、LPO积累的终末毒性产物以及抗氧化活性降低所引起的。
