Azizova O A, Vlasova I I
Biull Eksp Biol Med. 1993 Nov;116(11):485-7.
Platelet aggregation induced by native and oxidized low-density lipoproteins (LDL) was studied. The minimal LDL concentration necessary for platelet activation was no more than 0.2 mg/ml. The aggregation rate increased when LDL concentration rose from 0 to 0.4-0.6 mg/ml for native LDL and to 0.2-0.4 mg/ml for oxidized LDL. The platelet aggregation induced by oxidized LDL appeared to be higher than that induced by the same concentration of native LDL. The dependence of aggregation rate on the degree of LDL peroxidation was linear up to MDA concentration equal to 3-4 mg/ml. Further LDL peroxidation leads only to the negligible increase in the induced aggregation rate.
研究了天然和氧化型低密度脂蛋白（LDL）诱导的血小板聚集。血小板激活所需的最低LDL浓度不超过0.2mg/ml。对于天然LDL，当LDL浓度从0升至0.4 - 0.6mg/ml时，聚集率增加；对于氧化型LDL，当LDL浓度从0升至0.2 - 0.4mg/ml时，聚集率增加。氧化型LDL诱导的血小板聚集似乎高于相同浓度天然LDL诱导的血小板聚集。在丙二醛（MDA）浓度等于3 - 4mg/ml之前，聚集率对LDL过氧化程度的依赖性呈线性。进一步的LDL过氧化仅导致诱导聚集率的可忽略不计的增加。
