米库氯铵与艾司洛尔在大鼠体内神经肌肉效应的相互作用。

The interaction of the neuromuscular effects between mivacurium and esmolol in rats.

作者信息

Cheng R Y, Hau H R, Sun Y C, Chou C D, Liao K C, Chen C F, Tsai S K

机构信息

Department of Anesthesiology, Taipei Municipal Yang Ming Hospital, Taiwan, R.O.C.

出版信息

Acta Anaesthesiol Sin. 1995 Jun;33(2):97-100.

PMID:7663871

Abstract

BACKGROUND

To study the neuromuscular interaction between mivacurium and esmolol, we compared the neuromuscular actions of the ED90 dose of mivacurium both in the absence and presence of esmolol infusion.

METHODS

Twelve rats were anesthetized with urethane. Train-of-four stimulation was applied every 12 s to the sciatic nerve, and the electromyogram (EMG) response of the anterior tibial muscle was measured.

RESULTS

The ED50 and ED90 of mivacurium in rats were 144 +/- 7.3 micrograms/kg and 197 +/- 7.7 micrograms/kg, respectively. The maximal EMG depression produced by ED50 of mivacurium decreased significantly with esmolol treatment from 88.2 +/- 2.7% to 83.1 +/- 2.6% after esmolol infusion (p < 0.05). The onset time for 75% EMG depression was much shorter for control (44 +/- 6.3 s) than that of esmolol treatment (78.2 +/- 2.4 s; p < 0.05). There was no difference between their duration.

CONCLUSIONS

The results of this study demonstrated that esmolol does not potentiate the neuromuscular effect of mivacurium but antagonize the maximal neuromuscular block and decrease its onset time in rats.

摘要

背景

为研究米库氯铵与艾司洛尔之间的神经肌肉相互作用，我们比较了在输注艾司洛尔和未输注艾司洛尔情况下，米库氯铵ED90剂量的神经肌肉作用。

方法

12只大鼠用乌拉坦麻醉。每隔12秒对坐骨神经施加四个成串刺激，并测量胫前肌的肌电图（EMG）反应。

结果

米库氯铵在大鼠中的ED50和ED90分别为144±7.3微克/千克和197±7.7微克/千克。米库氯铵ED50产生的最大EMG抑制率在艾司洛尔治疗后显著降低，从88.2±2.7%降至输注艾司洛尔后的83.1±2.6%（p<0.05）。对照组达到75%EMG抑制的起效时间（44±6.3秒）比艾司洛尔治疗组（78.2±2.4秒；p<0.05）短得多。它们的持续时间没有差异。