Chang R Y, Chern S C, Chiang Y Y, Liou M D, Tseng K F, Tsai S K
Department of Anesthesiology, Taipei Municipal Yang-Ming Hospital, Taiwan, R.O.C.
Acta Anaesthesiol Sin. 1994 Sep;32(3):203-8.
To study the neuromuscular interactions between succinylcholine (Sch) and esmolol, we determined the dose-response relationship of Sch and the neuromuscular actions of the 3xED90 dose of Sch, both prior to and following esmolol pretreatment. Twenty rats were anaesthetized with urethane. Train-of-four stimulation was applied every 12 s to the sciatic nerve, and the electromyogram (EMG) of the tibialis anterior muscle was measured. The results showed that the potency of Sch decreased with esmolol pretreatment. The ED50 of Sch increased significantly, from 191 ug/kg to 227 ug/kg after esmolol infusion, p < 0.05. The duration of EMG depression achieved by the 3xED90 dose of Sch decreased significantly with esmolol pretreatment (12 min vs 14 min p < 0.05), and also the onset time was significantly longer (43 sec vs 28 sec, p < 0.05). There were no significant difference between groups with regard to the maximal block or recovery index. The results of two methods of study demonstrated that the pharmacological interaction between Sch and esmolol is antagonistic instead of potentiating.
为研究琥珀酰胆碱（Sch）与艾司洛尔之间的神经肌肉相互作用，我们在艾司洛尔预处理前后分别测定了Sch的剂量-反应关系以及Sch 3倍ED90剂量的神经肌肉作用。20只大鼠用乌拉坦麻醉。每隔12秒对坐骨神经施加四个成串刺激，并测量胫前肌的肌电图（EMG）。结果显示，艾司洛尔预处理后Sch的效能降低。Sch的ED50显著增加，艾司洛尔输注后从191μg/kg增至227μg/kg，p<0.05。Sch 3倍ED90剂量导致的EMG抑制持续时间经艾司洛尔预处理后显著缩短（12分钟对14分钟，p<0.05），且起效时间显著延长（43秒对28秒，p<0.05）。两组之间在最大阻滞或恢复指数方面无显著差异。两种研究方法的结果均表明，Sch与艾司洛尔之间的药理相互作用是拮抗而非协同作用。
