Kim K S, Kim K H, Shin W J, Yoo H K
Department of Anesthesiology, Hanyang University Hospital, Seoul, South Korea.
Anaesthesia. 1998 Feb;53(2):140-5. doi: 10.1046/j.1365-2044.1998.00283.x.
We compared the dose-response relationship and the neuromuscular blocking effects of mivacurium during infusions of esmolol in 40 anaesthetised rabbits. Train-of-four stimuli were applied every 10 s to the common peroneal nerve and the force of contraction of the tibialis anterior muscle was measured. Plasma cholinesterase activity decreased by 13% after esmolol infusion. The ED95 of mivacurium increased significantly from 29 (4.8) micrograms.kg-1 with placebo to 61 (9.8) micrograms.kg-1 during esmolol 100 micrograms.kg-1.min-1, 49 (8.2) micrograms.kg-1 during esmolol 300 micrograms.kg-1.min-1 and 54 (7.3) micrograms.kg-1 during esmolol 500 micrograms.kg-1.min-1, respectively (p < 0.001). The duration of neuromuscular block with mivacurium 0.16 mg.kg-1 was prolonged by 30% with esmolol due to diminished plasma cholinesterase activity (p < 0.05). Heart rate and mean arterial blood pressure decreased by 15% with esmolol (p < 0.05). The results of this study show that, in rabbits, esmolol decreased plasma cholinesterase activity, antagonised the neuromuscular blocking potency of mivacurium and prolonged its neuromuscular blocking effect.
我们比较了艾司洛尔输注期间米库氯铵在40只麻醉兔中的剂量-反应关系及神经肌肉阻滞作用。每隔10秒对腓总神经施加四个成串刺激，并测量胫前肌的收缩力。输注艾司洛尔后血浆胆碱酯酶活性下降了13%。米库氯铵的ED95从安慰剂组的29（4.8）微克·千克⁻¹显著增加到艾司洛尔100微克·千克⁻¹·分钟⁻¹时的61（9.8）微克·千克⁻¹、艾司洛尔300微克·千克⁻¹·分钟⁻¹时的49（8.2）微克·千克⁻¹以及艾司洛尔500微克·千克⁻¹·分钟⁻¹时的54（7.3）微克·千克⁻¹（p<0.001）。由于血浆胆碱酯酶活性降低，艾司洛尔使0.16毫克·千克⁻¹米库氯铵的神经肌肉阻滞持续时间延长了30%（p<0.05）。艾司洛尔使心率和平均动脉血压下降了15%（p<0.05）。本研究结果表明，在兔中，艾司洛尔降低血浆胆碱酯酶活性，拮抗米库氯铵的神经肌肉阻滞效能并延长其神经肌肉阻滞作用。
