儿童和成人尿中高香草酸和香草扁桃酸的尿肌酐校正参考范围。
Urinary creatinine adjusted reference ranges for homovanillic and vanillylmandelic acid in children and adults.
作者信息
Cole M, Craft A W, Parker L, Bell S, Seviour J A, McGill A C, Dale G
机构信息
Department of Child Health, University of Newcastle upon Tyne, Medical School, UK.
出版信息
Clin Chim Acta. 1995 Apr 30;236(1):19-32. doi: 10.1016/0009-8981(95)06031-1.
The relationship between urinary homovanillic acid (HVA), vanillylmandelic acid (VMA) and creatinine is investigated and reference ranges are constructed for HVA and VMA. A total of 769 urine samples were obtained from children and adults. The ratios HVA/creatinine and VMA/creatinine were highly correlated with creatinine concentration; hence, reference to creatinine was found to be an inappropriate adjustment for urinary dilution. An alternative method based upon linear regression is proposed. After allowing for differing levels of creatinine, HVA and VMA were found to be significantly correlated with age, height and weight for individuals aged less than 20 years. In those aged over 20 years, HVA was significantly correlated with weight and VMA with age. Differences between sexes were found in the levels of HVA and VMA, the exception being VMA in the over 20 age group. Reference ranges were constructed for HVA and VMA which are variously dependent upon creatinine, age, sex and weight.
研究了尿中高香草酸（HVA）、香草扁桃酸（VMA）与肌酐之间的关系，并构建了HVA和VMA的参考范围。共采集了769份儿童和成人的尿液样本。HVA/肌酐和VMA/肌酐的比值与肌酐浓度高度相关；因此，发现以肌酐作为尿液稀释的校正方法并不合适。提出了一种基于线性回归的替代方法。在考虑了不同水平的肌酐后，发现年龄小于20岁的个体中，HVA和VMA与年龄、身高和体重显著相关。在20岁以上的人群中，HVA与体重显著相关，VMA与年龄显著相关。发现HVA和VMA水平存在性别差异，20岁以上年龄组的VMA除外。构建了HVA和VMA的参考范围，这些范围因肌酐、年龄、性别和体重而异。
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