Cole M, Parker L, Craft A W, Bell S, Dale G, McGill A C, Seviour J A, Smith J
Department of Child Health, Medical School, Newcastle upon Tyne.
Arch Dis Child. 1993 Mar;68(3):376-8. doi: 10.1136/adc.68.3.376.
The relationship between homovanillic acid (HVA), vanillylmandelic acid (VMA), and creatinine in the urine of 6 month old babies has been studied and reference ranges in the form of centiles constructed for HVA and VMA against creatinine. Over 10,000 urine samples were collected from babies in four health districts in the north of England. HVA and VMA concentration, either independently or when divided by creatinine concentration, were dependent upon the absolute concentration of creatinine in the sample. After adjustment for creatinine significant differences in the mean concentration of HVA were found between sexes. No such differences were found for VMA. HVA and VMA were also found to be age dependent. Centiles were constructed using a procedure which makes no distributional assumptions about the data. The net effect of utilising these centiles was to increase the predictive value of a positive screening test from 20% to 40% without any increase in the false negative rate.
对6个月大婴儿尿液中的高香草酸（HVA）、香草扁桃酸（VMA）和肌酐之间的关系进行了研究，并以百分位数的形式构建了HVA和VMA相对于肌酐的参考范围。从英格兰北部四个健康区的婴儿中收集了超过10000份尿液样本。HVA和VMA的浓度，无论是单独的还是除以肌酐浓度后的，都取决于样本中肌酐的绝对浓度。在对肌酐进行校正后，发现两性之间HVA的平均浓度存在显著差异。VMA未发现此类差异。还发现HVA和VMA与年龄有关。百分位数是使用一种对数据不做分布假设的程序构建的。使用这些百分位数的净效果是将阳性筛查试验的预测值从20%提高到40%，而假阴性率没有任何增加。
