Aulard S, Lemeunier F, Hoogland C, Chaminade N, Brookfield J F, Biémont C
Laboratoire Populations, Génétique et Evolution, C.N.R.S., F-91198 Gif-sur-Yvette Cedex, France.
Chromosoma. 1995 Jul;103(10):693-9. doi: 10.1007/BF00344230.
The localization of the insertion sites of the 412 retrotransposable element was analysed by in situ hybridization to the polytene chromosomes of the genomes of males from a natural population of Drosophila melanogaster. Non-parametric statistical tests do not reveal any particular distribution of the insertion sites over the chromosomes, suggesting an apparently random distribution of the 412 element. Aggregation and dispersion tests were highly significant with data of copy number (when all genomes are pooled, many copies may be at a given site), suggesting the existence of sites with high insertion frequency. Comparison with other data from the literature confirms the tendency for a low proportion of insertions on the X chromosome in comparison with the autosomes, a result in agreement with selection acting against the detrimental effect of the 412 element insertions.
通过对黑腹果蝇自然种群雄性个体基因组的多线染色体进行原位杂交，分析了412反转录转座元件插入位点的定位。非参数统计检验未揭示插入位点在染色体上的任何特定分布，这表明412元件的分布显然是随机的。对拷贝数数据进行的聚集和离散检验具有高度显著性（当所有基因组汇总时，给定位点可能存在许多拷贝），这表明存在插入频率高的位点。与文献中的其他数据进行比较证实，与常染色体相比，X染色体上的插入比例较低，这一结果与针对412元件插入的有害效应进行选择的作用一致。
