Hall P, Rosendahl I, Mattsson A, Einhorn S
Department of General Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Int J Cancer. 1995 Sep 4;62(5):519-22. doi: 10.1002/ijc.2910620505.
The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patients, 504 developed a second primary cancer of any type except NHL, compared to 301.9 expected, giving a standardized incidence ratio (SIR) of 1.7 [95% confidence interval (CI) 1.5-1.8]. The risk of SCCS and malignant melanoma in patients with NHL was 4.8 (95% CI 3.6-6.2; n = 54) and 1.7 (95% CI 0.8-3.1; n = 10), respectively. The hazard risk for a second malignancy was relatively constant over time, whereas the skin malignancies revealed the highest risks 3-10 years after initial diagnosis. Similarly, the risk of a secondary NHL was studied in patients with malignant melanoma and SCCS during the same period and found to be 1.3 (95% CI 0.8-2.1; n = 17) and 1.8 (95% CI 1.2-2.5; n = 34), respectively. The highest risk for NHL following malignant melanoma was seen 3-10 years after first diagnosis, while the highest risk following SCCS was observed 0-2 years after initial diagnosis. One of several possible explanations or the development of NHL and a skin malignancy in the same patient is an immunological defect caused by sun exposure.
斯德哥尔摩-哥特兰癌症登记处被用于评估一项临床观察结果，即非霍奇金淋巴瘤（NHL）患者患皮肤恶性黑色素瘤或鳞状细胞癌（SCCS）的风险增加，反之亦然。在1958年至1992年期间，共诊断出6176例NHL患者。在这些患者中，有504例发生了除NHL以外的任何类型的第二原发性癌症，而预期为301.9例，标准化发病比（SIR）为1.7[95%置信区间（CI）1.5 - 1.8]。NHL患者患SCCS和恶性黑色素瘤的风险分别为4.8（95%CI 3.6 - 6.2；n = 54）和1.7（95%CI 0.
