Kolotilova L V, Shablovskaia E A, Urin A I, Lomnitskaia V B, Vygovskaia T V
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jul(7):54-8.
The authors present data concerning the state of the microflora of the nasopharynx in the immunization of adults and schoolchildren with the living influenza vaccine for oral administration. During the vaccinal process there occurred qualitative changes in the microbial pattern of the nasopharynx and a reduction in the level of the salivary lysozyme. The most pronounced changes were seen after the first vaccination, when the seeding efficiency of the pathogenic staphylococcus the E. coli and the Pr. mirabilis increased considerably. At the same time the incidence of isolation of the pathogenic staphylococcus, neisseria, and hemolytic streptococcus was decreased. The mentioned changes in the microbial flora directly depended on the dynamics of the survival of the vaccine influenza virus.
作者介绍了关于口服活流感疫苗对成人和学龄儿童进行免疫接种时鼻咽部微生物群落状况的数据。在接种过程中，鼻咽部的微生物模式发生了质的变化，唾液溶菌酶水平降低。首次接种后变化最为明显，此时致病性葡萄球菌、大肠杆菌和奇异变形杆菌的定植效率大幅提高。与此同时，致病性葡萄球菌、奈瑟菌和溶血性链球菌的分离率下降。上述微生物群落的变化直接取决于疫苗流感病毒存活的动态情况。
