• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

作者信息

Froelich-Ammon S J, Osheroff N

机构信息

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

出版信息

J Biol Chem. 1995 Sep 15;270(37):21429-32. doi: 10.1074/jbc.270.37.21429.

DOI:10.1074/jbc.270.37.21429
PMID:7665550
Abstract
摘要

相似文献

1
Topoisomerase poisons: harnessing the dark side of enzyme mechanism.拓扑异构酶毒物：利用酶作用机制的阴暗面
J Biol Chem. 1995 Sep 15;270(37):21429-32. doi: 10.1074/jbc.270.37.21429.
2
Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs.近年来，双重拓扑异构酶 I 和 II 抑制剂作为抗癌药物的发展取得了进展。
Curr Med Chem. 2010;17(35):4270-90. doi: 10.2174/092986710793361252.
3
ICE bioassay. Isolating in vivo complexes of enzyme to DNA.ICE生物测定法。分离酶与DNA的体内复合物。
Methods Mol Biol. 2001;95:137-47. doi: 10.1385/1-59259-057-8:137.
4
Iridoids as DNA topoisomerase I poisons.环烯醚萜类作为DNA拓扑异构酶I的毒剂。
J Enzyme Inhib Med Chem. 2005 Aug;20(4):389-92. doi: 10.1080/14756360500141879.
5
F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action.F 11782，一种新型的表鬼臼毒素类拓扑异构酶I和II非嵌入型双重催化抑制剂，具有独特的作用机制。
Biochem Pharmacol. 2000 Apr 1;59(7):807-19. doi: 10.1016/s0006-2952(99)00382-2.
6
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases.探索DNA拓扑异构酶作为新型治疗药物治疗传染病的靶点。
Infect Disord Drug Targets. 2007 Mar;7(1):3-9. doi: 10.2174/187152607780090748.
7
Topoisomerase enzymes as drug targets.作为药物靶点的拓扑异构酶
Curr Opin Oncol. 1999 Nov;11(6):482-9. doi: 10.1097/00001622-199911000-00009.
8
Synthesis and biological activities of topopyrones.托泊酮类的合成及生物活性。
J Nat Prod. 2012 Apr 27;75(4):577-85. doi: 10.1021/np200777z. Epub 2012 Mar 30.
9
Yeast systems for demonstrating the targets of anti-topoisomerase II agents.用于展示抗拓扑异构酶II药物靶点的酵母系统。
Methods Mol Biol. 2001;95:315-27. doi: 10.1385/1-59259-057-8:315.
10
Inactivation of topoisomerase I or II may lead to recombination or to aberrant replication termination on both SV40 and yeast 2 micron DNA.拓扑异构酶I或II的失活可能导致SV40和酵母2微米DNA上的重组或异常复制终止。
Chromosoma. 1996 Oct;105(4):250-60. doi: 10.1007/BF02528774.

引用本文的文献

1
Synthesis of Novel Thiazole/Thiadiazole Conjugates of Fluoroquinolones as Potent Antibacterial and Antimycobacterial Agents.新型氟喹诺酮噻唑/噻二唑共轭物作为强效抗菌和抗分枝杆菌剂的合成
Chem Biol Drug Des. 2025 May;105(5):e70126. doi: 10.1111/cbdd.70126.
2
Use of Xenopus Egg Extracts to Study the Effects of Topoisomerase Poisons During Vertebrate DNA Replication.利用非洲爪蟾卵提取物研究拓扑异构酶毒物在脊椎动物DNA复制过程中的作用。
Methods Mol Biol. 2025;2928:151-172. doi: 10.1007/978-1-0716-4550-5_13.
3
Combined Treatment of Dendrosomal-Curcumin and Daunorubicin Synergistically Inhibit Cell Proliferation, Migration and Induce Apoptosis in A549 Lung Cancer Cells.
树枝状聚集体姜黄素与柔红霉素联合治疗协同抑制A549肺癌细胞的增殖、迁移并诱导其凋亡。
Adv Pharm Bull. 2023 Jul;13(3):539-550. doi: 10.34172/apb.2023.050. Epub 2022 Jul 2.
4
Therapeutic Targeting of DNA Replication Stress in Cancer.癌症中 DNA 复制应激的治疗靶向。
Genes (Basel). 2023 Jun 26;14(7):1346. doi: 10.3390/genes14071346.
5
Topoisomerases in Immune Cell Development and Function.免疫细胞发育和功能中的拓扑异构酶。
J Immunol. 2023 Jan 15;210(2):126-133. doi: 10.4049/jimmunol.2200650.
6
DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes.在培养的β细胞中的 DNA 损伤重现了在 1 型糖尿病中积累的衰老β细胞的特征。
Mol Metab. 2022 Aug;62:101524. doi: 10.1016/j.molmet.2022.101524. Epub 2022 Jun 2.
7
Proteomic Assessment of Extracellular Vesicles from Canine Tissue Explants as a Pipeline to Identify Molecular Targets in Osteosarcoma: PSMD14/Rpn11 as a Proof of Principle.犬组织外泌体的蛋白质组学评估作为一种鉴定骨肉瘤分子靶点的方法：PSMD14/Rpn11 作为原理验证。
Int J Mol Sci. 2022 Mar 17;23(6):3256. doi: 10.3390/ijms23063256.
8
Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.内生真菌：天然产物药物发现中的关键见解、新兴前景与挑战
Microorganisms. 2022 Feb 4;10(2):360. doi: 10.3390/microorganisms10020360.
9
The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in Genome Stability in .DNA拓扑异构酶结合蛋白1（TopBP1）在……基因组稳定性中的作用
Plants (Basel). 2021 Nov 24;10(12):2568. doi: 10.3390/plants10122568.
10
Molecular docking analysis of α-Topoisomerase II with δ-Carboline derivatives as potential anticancer agents.以δ-咔啉衍生物作为潜在抗癌剂的α-拓扑异构酶II的分子对接分析。
Bioinformation. 2021 Jan 31;17(1):249-265. doi: 10.6026/97320630017249. eCollection 2021.