人巨细胞病毒的DNA结合蛋白pUL57是急性感染期间免疫球蛋白M抗体反应的主要靶抗原。
The DNA-binding protein pUL57 of human cytomegalovirus is a major target antigen for the immunoglobulin M antibody response during acute infection.
作者信息
Vornhagen R, Hinderer W, Sonneborn H H, Bein G, Matter L, The T H, Jahn G, Plachter B
机构信息
Research Department, Biotest AG, Dreieich, Germany.
出版信息
J Clin Microbiol. 1995 Jul;33(7):1927-30. doi: 10.1128/jcm.33.7.1927-1930.1995.
Abstract
A small polypeptide from pUL57 of human cytomegalovirus was identified as a major target for the immunoglobulin M antibody response. This antigen seems to be superior to antigenic fragments from pp150 and p52 in the identification of sera from acutely infected patients. It may therefore represent an essential antigen for recombinant immunoglobulin M antibody tests for human cytomegalovirus.
摘要
人巨细胞病毒pUL57的一种小多肽被确定为免疫球蛋白M抗体反应的主要靶点。在识别急性感染患者的血清方面，这种抗原似乎优于来自pp150和p52的抗原片段。因此，它可能是用于人巨细胞病毒重组免疫球蛋白M抗体检测的一种关键抗原。
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