• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人巨细胞病毒的DNA结合蛋白pUL57是急性感染期间免疫球蛋白M抗体反应的主要靶抗原。

The DNA-binding protein pUL57 of human cytomegalovirus is a major target antigen for the immunoglobulin M antibody response during acute infection.

作者信息

Vornhagen R, Hinderer W, Sonneborn H H, Bein G, Matter L, The T H, Jahn G, Plachter B

机构信息

Research Department, Biotest AG, Dreieich, Germany.

出版信息

J Clin Microbiol. 1995 Jul;33(7):1927-30. doi: 10.1128/jcm.33.7.1927-1930.1995.

DOI:10.1128/jcm.33.7.1927-1930.1995
PMID:7665674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC228303/
Abstract

A small polypeptide from pUL57 of human cytomegalovirus was identified as a major target for the immunoglobulin M antibody response. This antigen seems to be superior to antigenic fragments from pp150 and p52 in the identification of sera from acutely infected patients. It may therefore represent an essential antigen for recombinant immunoglobulin M antibody tests for human cytomegalovirus.

摘要

人巨细胞病毒pUL57的一种小多肽被确定为免疫球蛋白M抗体反应的主要靶点。在识别急性感染患者的血清方面，这种抗原似乎优于来自pp150和p52的抗原片段。因此，它可能是用于人巨细胞病毒重组免疫球蛋白M抗体检测的一种关键抗原。

相似文献

1
The DNA-binding protein pUL57 of human cytomegalovirus is a major target antigen for the immunoglobulin M antibody response during acute infection.人巨细胞病毒的DNA结合蛋白pUL57是急性感染期间免疫球蛋白M抗体反应的主要靶抗原。
J Clin Microbiol. 1995 Jul;33(7):1927-30. doi: 10.1128/jcm.33.7.1927-1930.1995.
2
IgM-specific serodiagnosis of acute human cytomegalovirus infection using recombinant autologous fusion proteins.使用重组自体融合蛋白对急性人类巨细胞病毒感染进行IgM特异性血清学诊断。
J Virol Methods. 1996 Jun;60(1):73-80. doi: 10.1016/0166-0934(96)02047-2.
3
Immunoglobulin A-specific serodiagnosis of acute human cytomegalovirus infection by using recombinant viral antigens.利用重组病毒抗原对急性人巨细胞病毒感染进行免疫球蛋白A特异性血清学诊断。
J Clin Microbiol. 1996 Apr;34(4):1020-3. doi: 10.1128/jcm.34.4.1020-1023.1996.
4
Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2 (UL44 and UL57) detects active infection in patients with chronic fatigue syndrome.使用来自基因产物p52和CM2（UL44和UL57）的巨细胞病毒早期抗原进行免疫测定，可检测慢性疲劳综合征患者的活动性感染。
J Clin Pathol. 2008 May;61(5):623-6. doi: 10.1136/jcp.2007.050633. Epub 2007 Nov 23.
5
Humoral immune response against human cytomegalovirus (HCMV)-specific proteins after HCMV infection in lung transplantation as detected with recombinant and naturally occurring proteins.用重组蛋白和天然蛋白检测肺移植中巨细胞病毒（HCMV）感染后针对HCMV特异性蛋白的体液免疫反应。
Clin Diagn Lab Immunol. 1995 Mar;2(2):214-8. doi: 10.1128/cdli.2.2.214-218.1995.
6
Antibody response to recombinant lambda gt11 fusion proteins in cytomegalovirus infection.巨细胞病毒感染中对重组λgt11融合蛋白的抗体反应。
J Clin Microbiol. 1989 Oct;27(10):2324-7. doi: 10.1128/jcm.27.10.2324-2327.1989.
7
Early serodiagnosis of acute human cytomegalovirus infection by enzyme-linked immunosorbent assay using recombinant antigens.利用重组抗原通过酶联免疫吸附测定法对急性人巨细胞病毒感染进行早期血清学诊断。
J Clin Microbiol. 1994 Apr;32(4):981-6. doi: 10.1128/jcm.32.4.981-986.1994.
8
Comparative immunoblot analysis with ten different, partially overlapping recombinant fusion proteins derived from five different cytomegalovirus proteins.
New Microbiol. 1995 Apr;18(2):223-8.
9
Reactivity to p52 and CM2 recombinant proteins in primary human cytomegalovirus infection with a microparticle agglutination assay.采用微粒凝集试验检测原发性人巨细胞病毒感染中对p52和CM2重组蛋白的反应性。
Clin Diagn Lab Immunol. 2000 Jul;7(4):536-9. doi: 10.1128/CDLI.7.4.536-539.2000.
10
Pattern of the epitope-specific IgG/IgM response against human cytomegalovirus in patients with multiple myeloma.多发性骨髓瘤患者针对人巨细胞病毒的表位特异性IgG/IgM反应模式
Clin Vaccine Immunol. 2013 Aug;20(8):1298-304. doi: 10.1128/CVI.00317-13. Epub 2013 Jun 19.

引用本文的文献

1
Development of recombinant antigen array for simultaneous detection of viral antibodies.用于同时检测病毒抗体的重组抗原阵列的开发。
PLoS One. 2013 Sep 13;8(9):e73842. doi: 10.1371/journal.pone.0073842. eCollection 2013.
2
Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant.母亲、胎儿及新生儿人巨细胞病毒感染的诊断与管理
Clin Microbiol Rev. 2002 Oct;15(4):680-715. doi: 10.1128/CMR.15.4.680-715.2002.
3
Cross-reactivity of Epstein-Barr virus-specific immunoglobulin M antibodies with cytomegalovirus antigens containing glycine homopolymers.爱泼斯坦-巴尔病毒特异性免疫球蛋白M抗体与含有甘氨酸同聚物的巨细胞病毒抗原的交叉反应性。
Clin Diagn Lab Immunol. 2001 Jul;8(4):747-56. doi: 10.1128/CDLI.8.4.747-756.2001.
4
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.自身免疫中的巨细胞病毒：T细胞对病毒抗原和自身抗原谷氨酸脱羧酶的交叉反应性。
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3988-91. doi: 10.1073/pnas.071050898.
5
Reactivity to p52 and CM2 recombinant proteins in primary human cytomegalovirus infection with a microparticle agglutination assay.采用微粒凝集试验检测原发性人巨细胞病毒感染中对p52和CM2重组蛋白的反应性。
Clin Diagn Lab Immunol. 2000 Jul;7(4):536-9. doi: 10.1128/CDLI.7.4.536-539.2000.
6
Development and clinical evaluation of a recombinant-antigen-based cytomegalovirus immunoglobulin M automated immunoassay using the Abbott AxSYM analyzer.使用雅培AxSYM分析仪的基于重组抗原的巨细胞病毒免疫球蛋白M自动免疫分析方法的开发与临床评估
J Clin Microbiol. 2000 Apr;38(4):1476-81. doi: 10.1128/JCM.38.4.1476-1481.2000.
7
Development of a new cytomegalovirus (CMV) immunoglobulin M (IgM) immunoblot for detection of CMV-specific IgM.开发一种用于检测巨细胞病毒（CMV）特异性免疫球蛋白M（IgM）的新型巨细胞病毒（CMV）免疫球蛋白M（IgM）免疫印迹法。
J Clin Microbiol. 1998 Nov;36(11):3337-41. doi: 10.1128/JCM.36.11.3337-3341.1998.
8
Search for cytomegalovirus-specific immunoglobulin M: comparison between a new western blot, conventional western blot, and nine commercially available assays.巨细胞病毒特异性免疫球蛋白M的检测：新型蛋白质印迹法、传统蛋白质印迹法与九种市售检测方法的比较
Clin Diagn Lab Immunol. 1997 Jul;4(4):483-6. doi: 10.1128/cdli.4.4.483-486.1997.
9
A novel Western blot test containing both viral and recombinant proteins for anticytomegalovirus immunoglobulin M detection.一种用于检测抗巨细胞病毒免疫球蛋白M的新型蛋白质印迹试验，其包含病毒蛋白和重组蛋白。
J Clin Microbiol. 1997 Feb;35(2):393-7. doi: 10.1128/jcm.35.2.393-397.1997.
10
Immunoglobulin A-specific serodiagnosis of acute human cytomegalovirus infection by using recombinant viral antigens.利用重组病毒抗原对急性人巨细胞病毒感染进行免疫球蛋白A特异性血清学诊断。
J Clin Microbiol. 1996 Apr;34(4):1020-3. doi: 10.1128/jcm.34.4.1020-1023.1996.

本文引用的文献

1
Early serodiagnosis of acute human cytomegalovirus infection by enzyme-linked immunosorbent assay using recombinant antigens.利用重组抗原通过酶联免疫吸附测定法对急性人巨细胞病毒感染进行早期血清学诊断。
J Clin Microbiol. 1994 Apr;32(4):981-6. doi: 10.1128/jcm.32.4.981-986.1994.
2
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.以谷胱甘肽S-转移酶融合形式在大肠杆菌中表达的多肽的一步纯化。
Gene. 1988 Jul 15;67(1):31-40. doi: 10.1016/0378-1119(88)90005-4.
3
Expression of the Epstein-Barr virus 138-kDa early protein in Escherichia coli for the use as antigen in diagnostic tests.
Gene. 1986;42(3):303-12. doi: 10.1016/0378-1119(86)90234-9.
4
Use of T7 RNA polymerase to direct expression of cloned genes.使用T7 RNA聚合酶指导克隆基因的表达。
Methods Enzymol. 1990;185:60-89. doi: 10.1016/0076-6879(90)85008-c.
5
Management of cytomegalovirus disease with antiviral drugs.
Rev Infect Dis. 1990 Sep-Oct;12 Suppl 7:S849-60. doi: 10.1093/clinids/12.supplement_7.s849.
6
Cytomegalovirus antigenemia.
Rev Infect Dis. 1990 Sep-Oct;12 Suppl 7:S734-44.
7
Serodiagnosis of infectious mononucleosis by using recombinant Epstein-Barr virus antigens and enzyme-linked immunosorbent assay technology.利用重组爱泼斯坦-巴尔病毒抗原和酶联免疫吸附测定技术进行传染性单核细胞增多症的血清学诊断。
J Clin Microbiol. 1990 Oct;28(10):2305-11. doi: 10.1128/jcm.28.10.2305-2311.1990.
8
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.人巨细胞病毒AD169株序列的蛋白质编码内容分析。
Curr Top Microbiol Immunol. 1990;154:125-69. doi: 10.1007/978-3-642-74980-3_6.
9
Quantitative measurement of cytomegalovirus-specific IgG and IgM antibodies in relation to cytomegalovirus antigenaemia and disease activity in kidney recipients with an active cytomegalovirus infection.肾移植受者发生活动性巨细胞病毒感染时，巨细胞病毒特异性IgG和IgM抗体与巨细胞病毒血症及疾病活动度的定量测定
Clin Exp Immunol. 1990 Apr;80(1):56-61. doi: 10.1111/j.1365-2249.1990.tb06441.x.
10
Structural organization of the conserved gene block of Herpesvirus saimiri coding for DNA polymerase, glycoprotein B, and major DNA binding protein.编码DNA聚合酶、糖蛋白B和主要DNA结合蛋白的猴疱疹病毒保守基因块的结构组织。
Virology. 1990 Feb;174(2):533-42. doi: 10.1016/0042-6822(90)90107-3.