Becker M N, Brenner R, Atkinson N S
Department of Zoology, University of Texas at Austin 78712-1064, USA.
J Neurosci. 1995 Sep;15(9):6250-9. doi: 10.1523/JNEUROSCI.15-09-06250.1995.
The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development. It is expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. The promoter has been cloned and shown to direct expression in the same pattern as the endogenous gene in both neural and epithelial-derived cells. During pupariation and embryogenesis, slo is expressed in muscles many hours prior to the appearance of functional channels.
果蝇慢poke（slo）基因编码一种与脊椎动物大电导钙激活钾（BK）通道同源的钙激活钾通道亚基。我们研究了slo在整个发育过程中的表达情况。它在肌肉细胞、中枢神经系统和外周神经系统的神经元、蘑菇体、胚胎和幼虫中肠的有限数量细胞以及上皮来源的气管细胞中表达。该基因的启动子已被克隆，并显示在神经细胞和上皮来源的细胞中均以与内源性基因相同的模式指导表达。在化蛹和胚胎发生过程中，slo在功能性通道出现前数小时就在肌肉中表达。
