Thakker N, Davies R, Horner K, Armstrong J, Clancy T, Guy S, Harris R, Sloan P, Evans G
Department of Medical Genetics, St Mary's Hospital, Manchester, UK.
J Med Genet. 1995 Jun;32(6):458-64. doi: 10.1136/jmg.32.6.458.
A weighted scoring system (Dental Panoramic Radiograph Score) taking into consideration the nature, extent, and site of osseous and dental changes on dental panoramic radiographs in familial adenomatous polyposis is described. The weighting takes into consideration the incidence of the anomaly in the general population. The reliability of the system was tested by application to 85 people known to be affected by clinical or mutation analysis, 30 people lacking mutation in the adenomatous polyposis gene, and 19 people shown to be at low risk (< 1%) by linkage analysis. Using the highest thresholds, a specificity of 100% and sensitivity of approximately 68% was obtained. If all positive findings were considered as significant, sensitivity was increased to approximately 82% but the specificity was reduced to approximately 88%. Significant DPRS findings were observed at a significantly higher frequency in patients aged over 20 compared to the patients aged 20 and under. Overall, approximately 68% of the affected subjects had significant changes, and approximately 18% had normal appearance on DPR, with the remainder having changes classified as minimal or equivocal.
本文描述了一种加权评分系统（牙科全景X线片评分），该系统考虑了家族性腺瘤性息肉病患者牙科全景X线片中骨与牙齿变化的性质、范围及部位。加权过程考虑了该异常在普通人群中的发生率。通过将该系统应用于85名经临床或突变分析确诊患病的患者、30名腺瘤性息肉病基因突变阴性者以及19名经连锁分析显示低风险（<1%）者，对该系统的可靠性进行了测试。采用最高阈值时，特异性为100%，敏感性约为68%。若将所有阳性结果均视为有意义，则敏感性提高至约82%，但特异性降至约88%。与20岁及以下患者相比，20岁以上患者中观察到显著牙科全景X线片评分结果的频率显著更高。总体而言，约68%的患病受试者有显著变化，约18%的受试者牙科全景X线片表现正常，其余受试者的变化分类为轻微或不明确。
