Weidner F
Arch Dermatol Res (1975). 1975 Dec 10;254(2):215-24. doi: 10.1007/BF00586895.
The histotopical distribution of IgD and fibrin was examined in skin lesions of 12 patients with cutaneous vasculitis, by means of the direct IF method. IgD was found in 9 cases mostly in a striking fixation to the PMN-leucocytic inflammation cells. Homogeneous depositions of IgD in cutaneous blood vessel walls were seen twice. In 3 cases with older, lympho-histiocytic infiltrations, IgD was lacking. Fibrin was constantly present in the blood vessel walls of fresh and older vasculitis lesions, and showed up in the regions of "fibrinoid necrosis" in form of distorted vascular rings. Although neither IgD nor fibrin appear in a disease-specific histotopical distribution, their simultaneous in vivo demonstration, connected with the result of vascular bound complement, is a good aid to substantiate the diagnosis of cutaneous vasculitis.
采用直接免疫荧光法，对12例皮肤血管炎患者皮损处的IgD和纤维蛋白进行组织学分布检测。在9例患者中发现IgD，大多显著定位于中性粒细胞炎症细胞。在皮肤血管壁可见两次IgD的均匀沉积。在3例有较陈旧的淋巴细胞 - 组织细胞浸润的病例中，未检测到IgD。纤维蛋白持续存在于新鲜和陈旧血管炎病变的血管壁中，并以扭曲的血管环形式出现在“纤维蛋白样坏死”区域。虽然IgD和纤维蛋白均未呈现疾病特异性的组织学分布，但它们在体内的同时显示，结合血管结合补体的结果，有助于证实皮肤血管炎的诊断。
