Zimmermann-Seydoux G, Rontogianni D, Zimmermann A
Pathologisches Institut, Universität, Bern.
Pathologe. 1995 Jul;16(4):262-8. doi: 10.1007/s002920050100.
Liver tissue from 14 female patients with primary biliary cirrhosis (PBC; stages I-IV) was systematically investigated for the prevalence and distribution of dendritic antigen-presenting cells. Dendritic cells (DCs) were immunhistochemically identified by use of anti-S 100 protein and KiMlp antibodies. We confirm previous findings that, in early PBC, S 100 protein-positive DCs can be detected within the lining of bile duct epithelia. However, the present study disclosed that S 100 protein- and KiMlp-positive DCs regularly occur in piece-meal necroses (PMNs) developing in PBC-associated chronic hepatitis. DCs in PMNs were observed in all PBC stages, but were most prominent in late-stage PBC. These findings suggest that autoimmune tissue damage in PBC may not be limited to bile ducts, but may also ensue in hepatic parenchyma, producing the pattern of chronic hepatitis with signs of activity.
对14例原发性胆汁性肝硬化（PBC；I-IV期）女性患者的肝组织进行了系统研究，以确定树突状抗原呈递细胞的患病率和分布情况。通过使用抗S 100蛋白和KiMlp抗体，免疫组织化学鉴定树突状细胞（DCs）。我们证实了先前的研究结果，即在早期PBC中，可在胆管上皮内衬中检测到S 100蛋白阳性的DCs。然而，本研究发现，S 100蛋白和KiMlp阳性的DCs经常出现在PBC相关慢性肝炎中出现的碎片状坏死（PMN）中。在所有PBC阶段均观察到PMN中的DCs，但在晚期PBC中最为明显。这些发现表明，PBC中的自身免疫性组织损伤可能不限于胆管，也可能在肝实质中发生，产生具有活动迹象的慢性肝炎模式。
