Clarke S N, Parker L A
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):505-8. doi: 10.1016/0091-3057(95)00042-u.
Morphine pretreatment attenuates aversive taste reactions elicited by quinine solution when assessed by the taste reactivity test. To determine whether this effect changes across trials, rats were administered morphine (2 mg/kg, subcutaneously) 30 min before a 5-min intraoral infusion of quinine solution (0.05%) on each of eight trials. Neither tolerance nor sensitization developed to morphine-induced attenuation of quinine aversiveness; morphine suppressed quinine-elicited aversive reactions on each trial. In addition, when tested in the absence of morphine, rats displayed a reduced aversion to quinine, suggesting that quinine became conditionally less aversive following previous pairings with morphine.
当通过味觉反应测试进行评估时，吗啡预处理可减轻奎宁溶液引发的厌恶味觉反应。为了确定这种效应在多次试验中是否会发生变化，在八项试验中的每一项试验中，大鼠在口腔内输注5分钟奎宁溶液（0.05%）前30分钟皮下注射吗啡（2毫克/千克）。对吗啡诱导的奎宁厌恶感减弱既未产生耐受性也未产生敏化作用；吗啡在每次试验中均抑制了奎宁引发的厌恶反应。此外，在没有吗啡的情况下进行测试时，大鼠对奎宁的厌恶感降低，这表明在先前与吗啡配对后，奎宁的条件性厌恶感降低。
