Haller J
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Physiol Behav. 1995 Jul;58(1):101-6. doi: 10.1016/0031-9384(95)00030-m.
Alpha-2 adrenoceptor antagonists remove the presynaptic negative feed-back control of norepinephrine release, by this enhancing the naturally occurring adrenergic activation. Male Long-Evans rats were injected with 1 mg/kg CH-38083, an alpha 2 adrenoceptor blocker. Twenty minutes later a size matched Wistar or Long-Evans opponent, respectively, was introduced in their home cage for 15 min (the Wistar strain is more aggressive than the Long-Evans in these circumstances). The treatment increased the number of biting attacks several folds in both situations. The correlations existing between the behavior of the intruder and the aggressiveness of the resident (treated) rat led to the conclusion that the catecholaminergic treatment increased the sensitivity of the animals to the behavioral actions of the intruder. The treated animals responded in an exaggerated fashion compared to their saline treated counterparts. An increase in the corticosterone response of the treated rats paralleled the increase in attack frequency, and seemed not to depend on the challenge received from the intruder.
α-2肾上腺素能受体拮抗剂消除了去甲肾上腺素释放的突触前负反馈控制，从而增强了自然发生的肾上腺素能激活。给雄性Long-Evans大鼠注射1mg/kg的α2肾上腺素能受体阻滞剂CH-38083。20分钟后，分别将体型匹配的Wistar或Long-Evans对手放入它们的笼中15分钟（在这些情况下，Wistar品系比Long-Evans更具攻击性）。在两种情况下，该处理都使咬击次数增加了几倍。入侵者的行为与受试（处理过的）大鼠的攻击性之间存在的相关性得出结论：儿茶酚胺能处理增加了动物对入侵者行为作用的敏感性。与用生理盐水处理的对应动物相比，处理过的动物反应过度。处理过的大鼠皮质酮反应的增加与攻击频率的增加平行，并且似乎不依赖于来自入侵者的挑战。
