Haller J, Barna I, Kovács J L
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Psychopharmacology (Berl). 1994 Aug;115(4):478-84. doi: 10.1007/BF02245571.
The effects of adrenergic activation on aggressiveness and the aggression induced endocrine changes were tested in rats. Alpha 2 adrenoceptor blockers were used for enhancing activation of the adrenergic system, and changes in aggressiveness were tested in resident-intruder contests. Three experiments were conducted. In experiment 1, saline injected rats responded to the presence of an opponent by aggression and the increase in plasma ACTH and corticosterone. Intraperitoneal administration of 1 mg/kg CH-38083 (an alpha 2 adrenoceptor antagonist) produced a several fold increase in clinch fighting and mutual upright scores, and also further enhanced the plasma ACTH and corticosterone response. In experiment 2, the effect of three doses (0.5, 1 and 2 mg/kg) of three different alpha 2 adrenoceptor blockers CH-38083, idazoxan and yohimbine were tested. All the substances increased aggression at 0.5 and 1 mg/kg; at 2 mg/kg the effect of idazoxan and yohimbine disappeared, while with CH-38083 an additional increase was obtained. In yohimbine treated animals the enhancement of aggression was reduced already at 1 mg/kg. In experiment 3, indomethacin, a potent inhibitor of the catecholamine-induced ACTH release completely abolished the effects of the alpha 2 adrenoceptor antagonist CH-38083: the intensity of agonistic interactions, as well as ACTH and corticosterone plasma concentrations, returned to control levels. The possible role of catecholamines and the stress hormones in the activation of aggression is discussed.
在大鼠中测试了肾上腺素能激活对攻击性以及攻击诱导的内分泌变化的影响。使用α2肾上腺素能受体阻滞剂来增强肾上腺素能系统的激活，并在定居者 - 入侵者竞争中测试攻击性的变化。进行了三项实验。在实验1中，注射生理盐水的大鼠通过攻击以及血浆促肾上腺皮质激素（ACTH）和皮质酮的增加对对手的存在做出反应。腹腔注射1mg/kg的CH - 38083（一种α2肾上腺素能受体拮抗剂）使扭打争斗和相互直立得分增加了几倍，并且还进一步增强了血浆ACTH和皮质酮反应。在实验2中，测试了三种不同的α2肾上腺素能受体阻滞剂CH - 38083、咪唑克生和育亨宾的三种剂量（0.5、1和2mg/kg）的效果。所有物质在0.5和1mg/kg时均增加攻击性；在2mg/kg时，咪唑克生和育亨宾的效果消失，而CH - 38083则获得了额外的增加。在育亨宾处理的动物中，在1mg/kg时攻击性的增强就已经降低。在实验3中，吲哚美辛，一种儿茶酚胺诱导的ACTH释放的强效抑制剂，完全消除了α2肾上腺素能受体拮抗剂CH - 38083的作用：激动性相互作用的强度以及ACTH和皮质酮的血浆浓度恢复到对照水平。讨论了儿茶酚胺和应激激素在攻击激活中的可能作用。
