Haller J
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Pharmacol Biochem Behav. 1995 Aug;51(4):789-94. doi: 10.1016/0091-3057(95)00034-t.
Male Wistar rats were injected with CH-38083, an alpha 2-adrenoceptor blocker, after which they were challenged by a size-matched Wistar or Long-Evans opponent. In residents facing low-aggression opponents, the alpha 2-adrenoceptor blockade significantly reduced aggressiveness, whereas in those facing highly aggressive opponents the treatment significantly increased aggression scores compared to saline-treated controls, irrespective of the strain of the intruder. When the animals were treated with CH-38083, the frequency of biting attacks correlated significantly with the aggressiveness of the opponent in residents fighting with Wistar and Long-Evans rats. Similar correlations were not found in control (saline-injected) rats. The results suggest that the catecholaminergic activation caused by the alpha 2 receptor antagonist elicits a more efficient adaptation to the behavioral actions of the opponent. Plasma corticosterone levels were not influenced by the treatment, but this variable seemed to be correlated with the defensive behavior performed by the intruder.
给雄性Wistar大鼠注射α2 -肾上腺素能受体阻滞剂CH - 38083，之后让它们与体型匹配的Wistar或Long - Evans对手进行对抗。在面对低攻击性对手的实验鼠中，α2 -肾上腺素能受体阻断显著降低了攻击性，而在面对高攻击性对手的实验鼠中，与生理盐水处理的对照组相比，该处理显著提高了攻击得分，无论入侵者的品系如何。当用CH - 38083处理动物时，在与Wistar和Long - Evans大鼠战斗的实验鼠中，撕咬攻击的频率与对手的攻击性显著相关。在对照（注射生理盐水）大鼠中未发现类似的相关性。结果表明，α2受体拮抗剂引起的儿茶酚胺能激活引发了对对手行为动作更有效的适应性反应。血浆皮质酮水平不受该处理的影响，但这一变量似乎与入侵者表现出的防御行为相关。
