Chen B M, Grinnell A D
Jerry Lewis Neuromuscular Research Center, University of California at Los Angeles School of Medicine, 90024, USA.
Science. 1995 Sep 15;269(5230):1578-80. doi: 10.1126/science.7667637.
The stretch of a frog muscle within the physiological range can more than double the spontaneous and evoked release of neurotransmitter from its motor nerve terminals. Here, stretch enhancement of release was suppressed by peptides containing the sequence arginine-glycine-aspartic acid (RGD), which blocks integrin binding. Integrin antibodies also inhibited the enhancement obtained by stretching. Stretch enhancement depended on intraterminal calcium derived both from external calcium and from internal stores. Muscle stretch thus might enhance the release of neurotransmitters either by elevating internal calcium concentrations or by increasing the sensitivity of transmitter release to calcium in the nerve terminal.
青蛙肌肉在生理范围内的拉伸可使运动神经末梢神经递质的自发释放和诱发释放增加一倍以上。在此，含有精氨酸-甘氨酸-天冬氨酸序列（RGD）的肽抑制了拉伸对释放的增强作用，该序列可阻断整合素结合。整合素抗体也抑制了拉伸所产生的增强作用。拉伸增强作用依赖于源自细胞外钙和细胞内储存库的终末内钙。因此，肌肉拉伸可能通过提高细胞内钙浓度或增加神经末梢递质释放对钙的敏感性来增强神经递质的释放。
