The Virginia Tech Carilion Research Institute, School of Biomedical Engineering and Sciences, Virginia Tech, Roanoke, Virginia 24016, USA.
Nat Rev Neurosci. 2012 Dec;13(12):867-78. doi: 10.1038/nrn3383.
All cells are influenced by mechanical forces. In the brain, force-generating and load-bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal signalling and plasticity. Although the functions of mechanosensitive proteins have been thoroughly described in classical sensory systems, the effects of endogenous mechanical energy on cellular function in the brain have received less attention, and many working models in neuroscience do not currently integrate principles of cellular mechanics. An understanding of cellular-mechanical concepts is essential to allow the integration of mechanobiology into ongoing studies of brain structure and function.
所有细胞都会受到机械力的影响。在大脑中，产生力和承重的蛋白质会扭曲、转动、棘轮、弯曲、压缩、扩张和弯曲，以介导神经元信号和可塑性。尽管机械敏感蛋白的功能在经典感觉系统中已经得到了彻底描述，但内源性机械能对大脑中细胞功能的影响却受到较少关注，神经科学中的许多工作模型目前还没有整合细胞力学原理。理解细胞力学概念对于将机械生物学纳入大脑结构和功能的现有研究中是至关重要的。
