Tolkacheva N V, Borisenko S N, Kulakova S N, Levachev M M, Onsovich I N
Vopr Onkol. 1995;41(1):29-32.
Levels of lipid ligands in serum albumin from cancer patients were assayed versus tumor localization. Abnormal non-specific increase in albumin-bound lipids as well as in peroxidation products was found. Gas-liquid chromatography of different polynonsaturated fatty acids pointed to the enhancement of their metabolism via the omega 3 pathway. The despiralization-type changes in secondary structure of albumin identified by procedures of spectral analysis and the decline in reserve functional activity of protein in tumor patients were matched by a rise in levels of serum albumin-transported ligands. It is suggested that such increase in the ligand-binding ability of albumin provides a major adaptive factor involved in oncopatology.
对癌症患者血清白蛋白中的脂质配体水平与肿瘤定位进行了测定。发现白蛋白结合脂质以及过氧化产物出现异常非特异性增加。不同多不饱和脂肪酸的气液色谱分析表明其通过ω-3途径的代谢增强。通过光谱分析程序鉴定出的白蛋白二级结构的解螺旋型变化以及肿瘤患者蛋白质储备功能活性的下降与血清白蛋白转运配体水平的升高相匹配。有人提出，白蛋白配体结合能力的这种增加是肿瘤病理学中一个主要的适应性因素。
