Litvinov A V, Savchenko V G, Tsepova E L, Chemodurova L N
Ter Arkh. 1998;70(7):72-4.
The study of changes in functional activity of albumin ligand centers in the course of accumulation of metabolic products in the blood of hematological patients.
Blood serum albumin transport function (TF) was investigated in 22 and 24 patients with acute and chronic leukemia, respectively. Lipid analyser AKL-01 and the kit "Zond-Albumin" ("Zond", Moscow) were employed to assess total albumin concentration (TAC), effective albumin concentration (EAC), albumin binding reserve (ABR), the toxicity index (TI). The control group consisted of 38 blood donors. The findings were processed with statistical techniques.
In patients with manifest acute leukemia, ABR and TI decreased while TAC remained unchanged. Chronic leukemia patients had high EAC and close to control levels of ABR and TI. In terminal chronic leukemia ABR lowered, TI increased, TAC was high but EAC fell. In patients with chronic leukemia and acute leukemia remission changes in albumin TF was accompanied with growing TAC.
A decline of albumin TF was found in patients with manifest acute leukemia and terminal chronic leukemia. In non-terminal chronic leukemia and in remission of acute leukemia albumin TF was normal.
研究血液病患者血液中代谢产物积累过程中白蛋白配体中心功能活性的变化。
分别对22例急性白血病患者和24例慢性白血病患者的血清白蛋白转运功能（TF）进行了研究。采用脂质分析仪AKL - 01和“Zond -白蛋白”试剂盒（“Zond”，莫斯科）评估总白蛋白浓度（TAC）、有效白蛋白浓度（EAC）、白蛋白结合储备（ABR）、毒性指数（TI）。对照组由38名献血者组成。研究结果采用统计技术进行处理。
在明显急性白血病患者中，ABR和TI降低，而TAC保持不变。慢性白血病患者的EAC较高，ABR和TI接近对照水平。在晚期慢性白血病中，ABR降低，TI升高，TAC较高但EAC下降。在慢性白血病和急性白血病缓解期患者中，白蛋白TF的变化伴随着TAC的升高。
在明显急性白血病和晚期慢性白血病患者中发现白蛋白TF下降。在非晚期慢性白血病和急性白血病缓解期，白蛋白TF正常。
