现代人类的起源与亲缘关系：线粒体和核基因数据的比较
Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data.
作者信息
Jorde L B, Bamshad M J, Watkins W S, Zenger R, Fraley A E, Krakowiak P A, Carpenter K D, Soodyall H, Jenkins T, Rogers A R
机构信息
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA.
出版信息
Am J Hum Genet. 1995 Sep;57(3):523-38. doi: 10.1002/ajmg.1320570340.
To test hypotheses about the origin of modern humans, we analyzed mtDNA sequences, 30 nuclear restriction-site polymorphisms (RSPs), and 30 tetranucleotide short tandem repeat (STR) polymorphisms in 243 Africans, Asians, and Europeans. An evolutionary tree based on mtDNA displays deep African branches, indicating greater genetic diversity for African populations. This finding, which is consistent with previous mtDNA analyses, has been interpreted as evidence for an African origin of modern humans. Both sets of nuclear polymorphisms, as well as a third set of trinucleotide polymorphisms, are highly consistent with one another but fail to show deep branches for African populations. These results, which represent the first direct comparison of mtDNA and nuclear genetic data in major continental populations, undermine the genetic evidence for an African origin of modern humans.
为了检验关于现代人类起源的假说，我们分析了243名非洲人、亚洲人和欧洲人的线粒体DNA序列、30个核限制性位点多态性（RSP）以及30个四核苷酸短串联重复（STR）多态性。基于线粒体DNA构建的进化树显示出非洲分支很深，这表明非洲人群具有更高的遗传多样性。这一发现与之前的线粒体DNA分析结果一致，被解释为现代人类起源于非洲的证据。两组核多态性以及第三组三核苷酸多态性彼此高度一致，但未显示出非洲人群的深分支。这些结果代表了对主要大陆人群中线粒体DNA和核基因数据的首次直接比较，削弱了现代人类起源于非洲的遗传证据。
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