Donnelly M J, Cohen L T, Clark G M
Human Communication Research Centre, University of Melbourne, Australia.
Ann Otol Rhinol Laryngol Suppl. 1995 Sep;166:45-8.
Sodium hyaluronate has potential uses as an electrode lubricant in cochlear implant surgery. Deeper electrode insertions were achieved in six temporal bones implanted with sodium hyaluronate, compared to 22 patients implanted without sodium hyaluronate. Preliminary biosafety studies measuring hearing thresholds of six cats 4 months after implantation with dummy electrodes did not show evidence of ototoxicity caused by sodium hyaluronate. Until the biosafety studies are complete, we cannot recommend sodium hyaluronate for routine use, but the results so far are promising.
透明质酸钠在人工耳蜗植入手术中具有作为电极润滑剂的潜在用途。与22例未使用透明质酸钠植入的患者相比，在6例植入透明质酸钠的颞骨中实现了更深的电极插入。在使用虚拟电极植入6只猫4个月后测量听力阈值的初步生物安全性研究中，未显示透明质酸钠引起耳毒性的证据。在生物安全性研究完成之前，我们不能推荐将透明质酸钠用于常规用途，但迄今为止的结果很有前景。
