与16型人乳头瘤病毒相比，18型人乳头瘤病毒与成纤维细胞瘤中较少的细胞凋亡相关。
Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16.
作者信息
Arends M J, Wyllie A H, Bird C C
机构信息
Department of Pathology, University Medical School, Edinburgh, UK.
出版信息
Br J Cancer. 1995 Sep;72(3):646-9. doi: 10.1038/bjc.1995.388.
Abstract
In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.
摘要
在人类宫颈肿瘤中，18型人乳头瘤病毒（HPV）的癌症/宫颈上皮内瘤变（CIN）患病率高于16型HPV。与对照组相比，用16型或18型HPV基因组转染的大鼠成纤维细胞衍生的纤维肉瘤显示凋亡增加。然而，18型HPV与明显少于16型HPV的凋亡相关，这为与18型HPV相关的进展更快的宫颈肿瘤提供了一种可能的解释。
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