人类癌症中基因组不稳定的机制：来自人乳头瘤病毒癌蛋白研究的见解。
Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.
作者信息
Duensing Stefan, Münger Karl
机构信息
Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA.
出版信息
Int J Cancer. 2004 Mar 20;109(2):157-62. doi: 10.1002/ijc.11691.
PMID:14750163
Abstract
Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.
摘要
基因组不稳定是大多数人类癌症的一个标志，包括高危型人乳头瘤病毒（HPV）相关的肛门生殖器肿瘤形成。两种由HPV编码的癌蛋白E6和E7可独立诱导染色体异常。我们总结了关于HPV诱导基因组不稳定的当前知识状态，并在人类致癌作用的背景下讨论其意义。
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