Nikonenko B V, Apt A S, Mezhlumova M V, Pospelov L E, Moroz A M
Vestn Ross Akad Med Nauk. 1995(7):24-8.
The paper discusses the genetic control of and the mechanisms of protective antituberculous immunity following BCG vaccination in inbred mice. The following genetic systems H-2 (B10.M)(H-2f) and B10.SM (H-2v) congenics were not protected with a high dose of BCG vaccine); Xid (X-linked immunodeficiency) CBA/N mice were not protected with regularly protective doses of BCG vaccine; Tbc-1 (I/St mice (Tbc-1s) were hypersensitive to tuberculosis. In two genetic systems (H-2 and xid), a distinct genetic control of susceptibility to primary tuberculosis and efficacy of BCG vaccination was demonstrated.
本文讨论了近交系小鼠接种卡介苗后保护性抗结核免疫的遗传控制及机制。以下遗传系统：H-2（B10.M）（H-2f）和B10.SM（H-2v）同源近交系小鼠对高剂量卡介苗疫苗无保护作用；Xid（X连锁免疫缺陷）CBA/N小鼠对常规保护性剂量的卡介苗疫苗无保护作用；Tbc-1（I/St小鼠（Tbc-1s）对结核病过敏。在两个遗传系统（H-2和xid）中，证明了对原发性结核易感性和卡介苗接种效果存在明显的遗传控制。
