Mano M T, Bexis S, Abeywardena M Y, McMurchie E J, King R A, Smith R M, Head R J
CSIRO Division of Human Nutrition, Adelaide, Australia.
Blood Press. 1995 May;4(3):177-86. doi: 10.3109/08037059509077591.
The effect of dietary fish oils on development of hypertension and vascular response in vitro were studied in rats and a primate. Dietary fish oils (MaxEPA and an n-3 ethyl ester concentrate of higher EPA and DHA content) were administered to spontaneously hypertensive (SHR), stroke-prone spontaneously hypertensive (SHR-SP) and a backcross of SHR and Wistar Kyoto (SHR/WKY) rats from 4-16 weeks of age. Blood pressure was monitored during the feeding period and vascular responses measured in the aorta and mesenteric vascular bed in vitro. Depending on the strain of rat used and the composition of the fish oil the attenuation in blood pressure was 10-26 mmHg. Fish oils attenuated the response mediated by sympathetic nerve stimulation or intralumenal norepinephrine in the perfused mesenteric vascular bed preparation from the SHR. This attenuation was more pronounced for fish oils enriched with eicosapentaenoic acid and docosahexaenoic acid and was more prominent in the SHR and SHR/WKY backcross than it was in the SHR-SP. Prostanoid synthesis or nitric oxide modulation of alpha-adrenoceptor responses were shown not to be involved in the attenuation of vascular responses produced by fish oil. The maximum contraction of aortic ring preparations in response to norepinephrine (NE) was significantly smaller in SHR than WKY rats fed olive oil and for SHR rats maintained on fish oils the contraction was close to WKY olive oil values. Evidence was obtained also for a modulation of vasoconstrictor responses by dietary fish oils in the perfused mesenteric bed of the marmoset monkey.
在大鼠和一种灵长类动物中研究了膳食鱼油对高血压发展及体外血管反应的影响。从4至16周龄起，给自发性高血压大鼠（SHR）、易中风自发性高血压大鼠（SHR-SP）以及SHR与Wistar Kyoto大鼠的回交后代（SHR/WKY）喂食膳食鱼油（MaxEPA以及一种富含更高EPA和DHA含量的n-3乙酯浓缩物）。在喂食期间监测血压，并在体外测量主动脉和肠系膜血管床的血管反应。根据所用大鼠的品系和鱼油的成分，血压降低幅度为10至26 mmHg。鱼油减弱了SHR灌注肠系膜血管床制剂中由交感神经刺激或管腔内去甲肾上腺素介导的反应。富含二十碳五烯酸和二十二碳六烯酸的鱼油这种减弱作用更明显，并且在SHR和SHR/WKY回交后代中比在SHR-SP中更显著。研究表明，前列腺素合成或一氧化氮对α-肾上腺素能受体反应的调节不参与鱼油引起的血管反应减弱。与喂食橄榄油的WKY大鼠相比，SHR中主动脉环制剂对去甲肾上腺素（NE）的最大收缩明显较小，而对于喂食鱼油的SHR大鼠，其收缩接近WKY大鼠喂食橄榄油时的值。在狨猴的灌注肠系膜床中也获得了膳食鱼油对血管收缩反应有调节作用的证据。
