Hermand E, Leonardelli J, Tramu G
Encephale. 1975;1(4):375-82.
The antiovulatory effect of sulpiride is mediated via inhibition of the LH-RH release: when given during 10 days in guinea pigs, sulpiride is able to promote an increase of LH-RH immunoreactive substance in anterior hypothalamic and suprachiasmatic neurons. This storage probably related with inhibition of LH-RH release, is permitted by catecholamines, since metatyrosine administration prevent this sulpiride effect. On the other hand, when administered to hamsters sulpiride is able to promote stimulation of hypothalamic catecholaminergic neurons of tubero infundibular and anterior periventricularis nuclei. The hypothalamic aminergic action upon sulpiride antiovulatory effect is discussed.
舒必利的抗排卵作用是通过抑制促性腺激素释放激素（LH-RH）的释放介导的：在豚鼠身上连续给药10天时，舒必利能够促使下丘脑前部和视交叉上核中LH-RH免疫反应性物质增加。这种储存可能与LH-RH释放的抑制有关，儿茶酚胺可使其发生，因为给予间酪氨酸可阻止舒必利的这种作用。另一方面，当给仓鼠给药时，舒必利能够促进对漏斗结节和室周前核的下丘脑儿茶酚胺能神经元的刺激。文中讨论了下丘脑胺能对舒必利抗排卵作用的影响。
