Genari S C, Wada M L
Department of Cell Biology, UNICAMP, Campinas (SP), Brazil.
Cytobios. 1995;81(324):17-25.
Arising from a Vero cell line, an altered population was spontaneously obtained, which grew in multiple layers. Cytogenetic analyses revealed a higher polyploidy index (19%) than occurred in the initial population (5%). A modal chromosome number of 56 was found for the altered population, while the initial cell culture had only 54 chromosomes. Karyotypic studies showed that the extranumerary chromosomes were homologues of the 8th and the 27th pairs. The altered population probably resulted from a transformation of the initial line, and their transformed phenotypes may have been associated with the cytological differences.
从一株Vero细胞系中，自发获得了一个变异群体，该群体呈多层生长。细胞遗传学分析显示，其多倍体指数（19%）高于初始群体（5%）。变异群体的染色体众数为56条，而初始细胞培养物只有54条染色体。核型研究表明，额外的染色体是第8对和第27对染色体的同源染色体。变异群体可能是由初始细胞系转化而来，其转化表型可能与细胞学差异有关。
