Raymond J M, Capdenat E, Beyssac R, Delarche C, Malaurie F, Bussat S, Dumas F, Couzigou P, Janvier G, Amouretti M
Département d'Hépato-Gastroentérologie, Hôpital du Haut-Lévêque, CHU Bordeaux, Pessac.
Gastroenterol Clin Biol. 1995 Apr;19(4):373-7.
Achieving colonoscopy under general anaesthesia entails the problem of ambulatory-care anaesthesia, in particular because perception of patient's recovery determines to some extent the length of monitoring following colonoscopy. The aims of the study was to assess the quality of patient's recovery after a colonoscopy under general anaesthesia while using propofol, by means of psychomotor-tests. METHODS--Colonoscopy was performed in 40 patients according to the following anaesthetic protocol: induction: propofol 2 mg/kg, continuous support: propofol 10 mg/kg/h i.v. with a 50 mg bolus in case of insufficient sedation; series of 3 psychomotor-tests were performed the day before and 1 hour, 3 hours and 6 hours after colonoscopy. The 3 psychomotor-tests studied: coordination (Newman test), time-space orientation and short-term memory. RESULTS--Forty patients, 25 females and 15 males, underwent colonoscopy with general anaesthesia for an average time-period of 22 +/- 11 min. The mean dose of propofol used was 286 +/- 102 mg. Awakening was complete in all patients, according to physical criteria such as consciousness and cardiovascular status, 20 min after receiving colonoscopy. The average psychomotor-tests results over time were (as percentages of original values) (*P < 10(-3); **P < 0.05): [table: see text] At 6 hours, 35 patients (87.5%) had recovered to their original performance and at 3 hours, 30 patients (75%) retained 90% their former state as measured with 3 psychomotor-tests. Neither by age or sex nor by propofol doses used or length or anaesthesia, the study population differed significantly. CONCLUSION--Three hours after colonoscopy under general anaesthesia using propofol, 30 patients (75%) had recovered at least 90% to their initial performances. Newman test was the most disturbed but there was no predictive factor for the quality of recovery. Psychomotor-tests may be useful before authorizing early discharge after colonoscopy under general anaesthesia but other recommendations about conditions of discharge after sedation must be also implemented.
在全身麻醉下进行结肠镜检查会带来门诊麻醉的问题,特别是因为患者恢复情况的感知在一定程度上决定了结肠镜检查后监测的时长。本研究的目的是通过心理运动测试评估在全身麻醉下使用丙泊酚进行结肠镜检查后患者的恢复质量。方法——根据以下麻醉方案对40例患者进行结肠镜检查:诱导:丙泊酚2mg/kg;持续维持:丙泊酚10mg/(kg·h)静脉注射,若镇静不足则给予50mg推注;在结肠镜检查前一天以及检查后1小时、3小时和6小时进行一系列3项心理运动测试。所研究的3项心理运动测试为:协调性(纽曼测试)、时空定向和短期记忆。结果——40例患者,25例女性和15例男性,接受全身麻醉下的结肠镜检查,平均时长为22±11分钟。丙泊酚的平均使用剂量为286±102mg。根据意识和心血管状况等身体标准,所有患者在接受结肠镜检查后20分钟完全苏醒。随着时间推移,心理运动测试的平均结果(以原始值的百分比表示)(*P<10⁻³;**P<0.05):[表格:见正文]在6小时时,35例患者(87.5%)恢复到原来的表现,在3小时时,30例患者(75%)通过3项心理运动测试测量,保留了其先前状态的90%。研究人群在年龄、性别、丙泊酚使用剂量、麻醉时长方面均无显著差异。结论——在全身麻醉下使用丙泊酚进行结肠镜检查3小时后,30例患者(75%)至少恢复到其初始表现的90%。纽曼测试受干扰最大,但恢复质量没有预测因素。心理运动测试在全身麻醉下结肠镜检查后批准提前出院前可能有用,但还必须实施其他关于镇静后出院条件的建议。