Augthun M, Yildirim M, Spiekermann H, Biesterfeld S
Clinic for Prosthetic Dentistry, University of Aachen, Germany.
Int J Oral Maxillofac Implants. 1995 Jul-Aug;10(4):421-8.
Twenty Brånemark implants were placed with membranes (Gore-Tex Augmentation Material) as immediate or delayed implants in the extraction sockets of 15 patients. Membrane perforations through the mucous membrane occurred in 10 patients after 6 to 24 weeks and once after 2 weeks. Histologic examination of 15 tissue samples taken when the membrane was removed showed genuine bone regeneration in three patients, connective tissue regeneration with intermittent bone regeneration in eight patients, purely fibrous healing in two patients, and inflammatory granulation tissue in two patients. The high proportion of membrane perforations with immediate implants should be taken into account in the assessment and clinical application of this therapy principle.
在15名患者的拔牙窝中植入了20枚采用膜（戈尔特斯增强材料）的布伦马克种植体，作为即刻种植体或延期种植体。10名患者在6至24周后出现了穿过黏膜的膜穿孔，2周后出现过1次。在取出膜时采集的15份组织样本的组织学检查显示，3名患者有真正的骨再生，8名患者有结缔组织再生并伴有间歇性骨再生，2名患者为单纯纤维愈合，2名患者为炎性肉芽组织。在评估和临床应用这一治疗原则时，应考虑即刻种植体膜穿孔比例较高的情况。
