Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Collage of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.
Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University, Gwangneung, South Korea.
Sci Rep. 2018 Nov 8;8(1):16532. doi: 10.1038/s41598-018-34805-w.
To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery.
为了指导种植体周围牙槽骨缺损治疗中屏障膜的选择，我们评估了钛（Ti）网或 Bio-Gide 膜单独或联合使用引导骨再生（GBR）修复 Beagle 犬牙槽骨缺损的效果。从 3 只 Beagle 犬下颌前磨牙和第一磨牙拔牙后 6 个月，我们将种植体分配到 3 组中，并分别用以下膜组合覆盖：A 组：种植体+Bio-Oss+Ti 网，B 组：种植体+Bio-Oss+Bio-Gide，C 组：种植体+Bio-Oss+Ti 网+Bio-Gide。6 个月时，Micro-CT 显示 C 组的骨体积/总体积（BV/TV）、骨小梁数量（Tb.N）和骨小梁厚度（Tb.Th）明显大于其他两组，而骨小梁间距（Tb.Sp）明显小于其他两组，提示骨再生改善。C 组中 3 种荧光示踪染料条带之间的距离明显更大，表明新骨沉积更快。Bio-Oss 颗粒与新沉积的骨理想结合，C 组的骨厚度明显更大。这些发现表明，Bio-Gide 膜和钛网的联合使用可以有效修复种植体周围牙槽骨缺损，与单独使用钛网或 Bio-Gide 相比，可实现更强的骨再生，为临床种植手术提供了一种新的治疗概念。
