O'Riordan J I, Hayes J, Fitzgerald M X, Redmond J
Department of Neurology, St. Vincent's Hospital, Elm Park, Dublin.
Ir J Med Sci. 1995 Jul-Sep;164(3):207-8. doi: 10.1007/BF02967830.
The prevalence of peripheral nerve dysfunction was assessed in 24 randomly selected adult patients with cystic fibrosis. Median, peroneal and sural nerves were studied. In 15 patients (62%), one or more electrical abnormality were detected. In the median nerve, conduction velocity was slowed in 29% of sensory studies and 12.5% of motor studies; compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) amplitudes were normal. The CAMP was low in 17% of peroneal studies with motor conduction velocity slow in 8%. The sural SNAP was low in 17% and sensory nerve conduction velocity slow in 25%. Using a multiple regression analysis only age at diagnosis was identified as a significant predictor of peripheral nerve dysfunction (multiple R = 0.55; p < 0.01). This study demonstrates that mild peripheral nerve dysfunction is common in patients with cystic fibrosis. With the improving long term survival of these patients we predict that the prevalence and severity of this complication will increase.
对24例随机选取的成年囊性纤维化患者的周围神经功能障碍患病率进行了评估。研究了正中神经、腓总神经和腓肠神经。15例患者（62%）检测到一项或多项电异常。在正中神经中，29%的感觉研究和12.5%的运动研究中传导速度减慢；复合肌肉动作电位（CMAP）和感觉神经动作电位（SNAP）振幅正常。在17%的腓总神经研究中CMAP降低，8%的运动传导速度减慢。17%的腓肠神经SNAP降低，25%的感觉神经传导速度减慢。采用多元回归分析，仅诊断时的年龄被确定为周围神经功能障碍的显著预测因素（多元相关系数R = 0.55；p < 0.01）。本研究表明，轻度周围神经功能障碍在囊性纤维化患者中很常见。随着这些患者长期生存率的提高，我们预测这种并发症的患病率和严重程度将会增加。
