Barona M I, Arrunátegui A, Falabella R, Alzate A
Department of Internal Medicine, Universidad del Valle, Cali, Colombia.
J Am Acad Dermatol. 1995 Oct;33(4):621-5. doi: 10.1016/0190-9622(95)91282-7.
Previous epidemiologic studies of vitiligo have not included a sex- and age-matched population.
Our purpose was to attempt to determine possible risk factors and clinical differences associated with unilateral and bilateral vitiligo.
Two hundred thirty-four patients and 234 normal control subjects were examined and questioned.
Patients with unilateral vitiligo were younger and had an earlier age at onset. Koebner's phenomenon and halo nevus were infrequent in the total vitiligo group, but no difference between vitiligo types was observed. Subjects with bilateral vitiligo more frequently had light skin (types I, II, and III) and more commonly had an associated autoimmune disease.
Unilateral and bilateral vitiligo differ substantially in several clinical aspects, which suggests a different pathogenic mechanism for each condition.
以往白癜风的流行病学研究未纳入性别和年龄匹配的人群。
我们的目的是试图确定与单侧和双侧白癜风相关的可能危险因素及临床差异。
对234例患者和234例正常对照者进行了检查和询问。
单侧白癜风患者较年轻且发病年龄较早。同形反应和晕痣在整个白癜风组中不常见，但不同类型白癜风之间未观察到差异。双侧白癜风患者皮肤较白（I、II和III型）的情况更为常见，且更常伴有自身免疫性疾病。
单侧和双侧白癜风在几个临床方面存在显著差异，这表明每种情况的致病机制不同。
