Khurrum Huma, AlGhamdi Khalid M, Bedaiwi Khalid M, AlBalahi Naif Meshael
Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ann Dermatol. 2017 Jun;29(3):302-306. doi: 10.5021/ad.2017.29.3.302. Epub 2017 May 11.
The Koebner phenomenon (KP) is a common entity observed in dermatological disorders. The reported incidence of KP in vitiligo varies widely. Although the KP is frequently observed in patients with viltiligo, the associated factors with KP has not been established yet.
The aim is to estimate the prevalence of KP in vitiligo patients and to investigate the associated factors with KP among vitiligo characteristics.
A cross-sectional observational study was conducted using 381 vitiligo patients. Demographic and clinical information was obtained via the completion of Vitiligo European Task Force (VETF) questionnaires. Patients with positive history of KP were extracted from this vitiligo database. Multivariate analysis was performed to assess associations with KP.
The median age of cases was 24 years (range, 0.676). In total, 237 of the patients were male (62.2%). Vitiligo vulgaris was the most common type observed (152/381, 39.9%). Seventy-two percent (274/381) patients did not exhibit KP, whereas 28.1% (107/381) of patients exhibited this condition. Multivariable analysis showed the following to be independent factors with KP in patients with vitiligo: the progressive disease (odds ratio [OR], 1.82; 95% confidence interval [95% CI], 1.172.92; =0.041), disease duration longer than 5 years (OR, 1.92; 95% CI, 1.222.11; =0.003), and body surface area more than 2% (OR, 2.20; 95% CI, 1.263.24; <0.001).
Our results suggest that KP may be used to evaluate disease activity and investigate different associations between the clinical profile and course of vitiligo. Further studies are needed to predict the relationship between KP and responsiveness to therapy.
同形反应（KP）是皮肤科疾病中常见的一种现象。白癜风患者中同形反应的报告发病率差异很大。尽管白癜风患者中经常观察到同形反应，但与同形反应相关的因素尚未明确。
旨在评估白癜风患者中同形反应的患病率，并调查白癜风特征中与同形反应相关的因素。
对381例白癜风患者进行了一项横断面观察性研究。通过填写白癜风欧洲工作组（VETF）问卷获取人口统计学和临床信息。从该白癜风数据库中提取有同形反应阳性病史的患者。进行多变量分析以评估与同形反应的相关性。
病例的中位年龄为24岁（范围0.676岁）。总共有237例患者为男性（62.2%）。寻常型白癜风是最常见的类型（152/381，39.9%）。72%（274/381）的患者未表现出同形反应，而28.1%（107/381）的患者表现出这种情况。多变量分析显示，白癜风患者中与同形反应相关的独立因素如下：进展期疾病（比值比[OR]，1.82；95%置信区间[95%CI]，1.172.92；P = 0.041）、病程超过5年（OR，1.92；95%CI，1.222.11；P = 0.003）以及体表面积超过2%（OR，2.20；95%CI，1.263.24；P<0.001）。
我们的结果表明，同形反应可用于评估疾病活动度，并研究白癜风临床特征与病程之间的不同关联。需要进一步研究来预测同形反应与治疗反应之间的关系。
