Reynolds K, Darrigrand A, Roberts D, Knapik J, Pollard J, Duplantis K, Jones B
Occupational Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007, USA.
J Am Acad Dermatol. 1995 Oct;33(4):626-30. doi: 10.1016/0190-9622(95)91283-5.
Friction blisters are a common injury in sports activities and military operations. Blisters can compromise performance, so it is important to devise preventive strategies to reduce these injuries.
This study investigated the influence of an antiperspirant with emollient additives on frequency and severity of friction blisters, hot spots, and irritant dermatitis.
Twenty-three healthy men walked on a treadmill (1.39 m/sec, 1% grade) in a warm environment (28 degrees C, 25% relative humidity) carrying a total mass of 21 +/- 1 kg. For 4 consecutive days before the walk, the subjects' feet were treated with either (1) an antiperspirant (20% aluminum zirconium tetrachlorohydrex glycine concentration plus water) with emollient additives, (2) emollient additives alone (placebo control), or (3) nothing (nontreated). In two separate trials (1 month apart) each participant received the antiperspirant treatment and both control treatments (emollient [placebo] and no treatment).
No differences were seen among treatment conditions for sweat accumulation (p = 0.86), blister incidence (p = 0.36), hot spot incidence (p = 0.83), or blister severity (p = 0.31). Irritant dermatitis was not reported in any of the treatment conditions.
The use of an antiperspirant with emollients reduces irritant dermatitis but does not reduce total foot-sweat accumulation, blister or hot spot incidence, or blister severity.
摩擦水疱是体育活动和军事行动中常见的损伤。水疱会影响表现，因此制定预防策略以减少这些损伤很重要。
本研究调查了含有润肤添加剂的止汗剂对摩擦水疱、热点和刺激性皮炎的发生频率及严重程度的影响。
23名健康男性在温暖环境（28摄氏度，相对湿度25%）中，背负总质量为21±1千克的重物，以1.39米/秒的速度、1%的坡度在跑步机上行走。在行走前连续4天，受试者的双脚分别接受以下处理：（1）含有润肤添加剂的止汗剂（甘氨酸铝锆四氯化物浓度为20%加水）；（2）仅使用润肤添加剂（安慰剂对照）；或（3）不做处理（未治疗）。在两个独立的试验（间隔1个月）中，每位参与者都接受了止汗剂治疗以及两种对照治疗（润肤剂[安慰剂]和不治疗）。
在汗液积聚（p = 0.86）、水疱发生率（p = 0.36）、热点发生率（p = 0.83）或水疱严重程度（p = 0.31）方面，各治疗组之间未见差异。在任何治疗组中均未报告刺激性皮炎。
使用含有润肤剂的止汗剂可减少刺激性皮炎，但不能减少足部总汗液积聚、水疱或热点的发生率，也不能减轻水疱的严重程度。
