Hoshihara Y, Hashimoto M, Yamamoto T, Tanaka T, Iguchi D, Kimura T, Sugawara K, Fukuchi S, Takemoto T
Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
J Clin Gastroenterol. 1995;20 Suppl 1:S10-6. doi: 10.1097/00004836-199506001-00004.
We studied the detailed surface structure and changes in the regenerated mucosa during the course of healing of recurrent gastric ulcers treated with lansoprazole or famotidine, using a magnifying electronic endoscope (videoendoscope) and a dye contrast method. The detailed patterns of regenerated mucosa were classified into five types: membranous, spindle-shaped, palisade-shaped, cobblestone-shaped, and almost normal structure. Initially, the membranous regenerated mucosa appears at the ulcer margin and grows into the spindle- and palisade-shaped regenerated mucosa. These latter types of mucosa change gradually into the cobblestone-shaped type, which finally develops into an almost normal structure. Lansoprazole appeared to bring about more rapid growth and changes of the regenerated mucosa than famotidine, although the difference was not statistically significant. We suggest that it is useful, in the assessment of gastric ulcer therapy, to observe the detailed patterns of the regenerated mucosa during the healing process using a magnifying electronic endoscope.
我们使用放大电子内镜（视频内镜）和染料对比法，研究了用兰索拉唑或法莫替丁治疗复发性胃溃疡愈合过程中再生黏膜的详细表面结构及变化。再生黏膜的详细形态分为五种类型：膜状、纺锤形、栅栏状、鹅卵石状和几乎正常结构。最初，膜状再生黏膜出现在溃疡边缘，然后生长为纺锤形和栅栏状再生黏膜。后两种类型的黏膜逐渐转变为鹅卵石状，最终发展为几乎正常的结构。尽管差异无统计学意义，但兰索拉唑似乎比法莫替丁能使再生黏膜生长和变化得更快。我们建议，在评估胃溃疡治疗效果时，使用放大电子内镜观察愈合过程中再生黏膜的详细形态是有用的。
