Duthie R, Ling T W, Cheng A F, French G L
Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
J Infect. 1995 May;30(3):241-4. doi: 10.1016/s0163-4453(95)90808-0.
During a 5-year study of 2211 patients with clinically significant positive blood cultures in Hong Kong. Aeromonas spp. were isolated in 40 cases. Among 26 episodes in which a single species was isolated. 17 (65.4%) were identified as Aeromonas hydrophila. 8 (30.8%) as A. sobria and one (3.8%) as A. caviae. There were 14 episodes with a mixture of species. Of these, nine (64.3%) were identified as A. hydrophila, two (14.3%) as A. sobria, and two (14.3%) as A. caviae. One (7.1%) was an infection with both A. sobria and A. hydrophila. These polymicrobial infections were usually combined with the presence of Enterobacteriaceae. Hepatobiliary disease was the underlying problem in 24 cases (60.0%) and malignant neoplasia in 14 (35.0%) cases. Most patients presented with fever and leucocytosis. The mortality rate for A. sobria septicaemia was not significantly different from the average rate for all septicaemias. A total of 30 isolates was available for sensitivity testing with 17 antibiotics. More than 86.0% were resistant to ampicillin, and the addition of the beta-lactamase inhibitor sulbactam did not restore its activity. All strains tested were sensitive to cefotaxime, ceftazidime, aztreonam, imipenem, norfloxacin and ciprofloxacin.
在香港对2211例血培养临床意义阳性患者进行的一项为期5年的研究中，分离出40例气单胞菌属。在分离出单一菌种的26次发作中，17例（65.4%）被鉴定为嗜水气单胞菌，8例（30.8%）为温和气单胞菌，1例（3.8%）为豚鼠气单胞菌。有14次发作分离出多种菌种。其中，9例（64.3%）被鉴定为嗜水气单胞菌，2例（14.3%）为温和气单胞菌，2例（14.3%）为豚鼠气单胞菌。1例（7.1%）为温和气单胞菌和嗜水气单胞菌混合感染。这些多微生物感染通常与肠杆菌科细菌同时存在。肝胆疾病是24例（60.0%）的潜在问题，恶性肿瘤是14例（35.0%）的潜在问题。大多数患者表现为发热和白细胞增多。温和气单胞菌败血症的死亡率与所有败血症的平均死亡率无显著差异。共有30株分离菌可用于17种抗生素的敏感性测试。超过86.0%的菌株对氨苄西林耐药，添加β-内酰胺酶抑制剂舒巴坦并不能恢复其活性。所有测试菌株对头孢噻肟、头孢他啶、氨曲南、亚胺培南、诺氟沙星和环丙沙星敏感。
