大剂量静脉注射免疫球蛋白治疗多灶性运动神经病：一项双盲、安慰剂对照研究。
Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study.
作者信息
Van den Berg L H, Kerkhoff H, Oey P L, Franssen H, Mollee I, Vermeulen M, Jennekens F G, Wokke J H
机构信息
Rudolf Magnus Research School in the Neurosciences, Department of Neurology, University Hospital Utrecht, The Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):248-52. doi: 10.1136/jnnp.59.3.248.
Abstract
The effect of high dose intravenous immunoglobulin (IVIg) treatment was studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) in an open trial. The effect of IVIg treatment was confirmed for each patient in a single patient, double blind, placebo controlled trial. Four patients received two IVIg treatments and two placebo treatments, and two patients received one IVIg and one placebo treatment in a randomised order. Five out of six patients responded to IVIg but not to placebo. One patient responded to IVIg in the same manner as to placebo treatment. Thus IVIg treatment can lead to improvement of muscle strength in patients with MMN.
摘要
对6例多灶性运动神经病（MMN）患者进行了大剂量静脉注射免疫球蛋白（IVIg）治疗效果的研究。在一项开放性试验中，所有患者对治疗（连续5天给予0.4g/kg）均有反应。在一项单病例、双盲、安慰剂对照试验中，对每位患者IVIg治疗的效果进行了确认。4例患者按随机顺序接受了两次IVIg治疗和两次安慰剂治疗，2例患者接受了一次IVIg和一次安慰剂治疗。6例患者中有5例对IVIg有反应，但对安慰剂无反应。1例患者对IVIg的反应与对安慰剂治疗的反应相同。因此，IVIg治疗可使MMN患者的肌肉力量得到改善。
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